See Geographic
Atrophy clearly

close-up photo of blue-green eye

Why it is critical to recognize Geographic Atrophy (GA) at first sight

GA is an advanced form of age-related macular degeneration (AMD), a leading cause of significant vision loss worldwide.1-4

While lesion growth in GA may appear to proceed slowly,
the damage is progressive and associated with irreversible vision loss2,4

Multimodal imaging
can assist in diagnosing and monitoring lesion growth

mulitmodal imaging example labelled

FAF is currently the standard imaging technology for morphological assessment of GA5

OCT scans are used to provide important cross-sectional information for assessment of the integrity of retinal layers, evaluation of GA lesion area, and measurement of GA lesion growth5

Images courtesy of Mohammad Rafieetary, OD, Charles Retina Institute.
FAF=fundus autofluorescence; NIR=near infrared; OCT=optical coherence tomography.

Identify and refer patients with GA as early as possible

The patient burden

Explore the impact of GA on your patients’ quality of life.

The GA burden
Close up image of brown eye

Understanding complement

Discover how excessive complement activation can contribute to GA progression.

The role of complement
Microscopic image of macrophage

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References:

  1. Gehrs KM, Anderson DH, Johnson LV, Hageman GS. Age-related macular degeneration—emerging pathogenetic and therapeutic concepts. Ann Med. 2006;38(7):450-471. doi:10.1080/07853890600946724.
  2. Fleckenstein M, Mitchell P, Freund KB, et al. The progression of geographic atrophy secondary to age-related macular degeneration. Ophthalmology. 2018;125:369-390. doi:10.1016/j.ophtha.08.038.
  3. Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2(2):e106-116. doi:10.1016/S2214-109X(13)70145-1.
  4. Boyer DS, Schmidt-Erfurth U, van Lookeren Campagne M, et al. The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target. Retina. 2017;37(5):819-835. doi:10.1097/iae.0000000000001392.
  5. Sadda SR, Chakravarthy U, Birch DG, et al. Clinical endpoints for the study of geographic atrophy secondary to age-related macular degeneration. Retina. 2016;36(10):1806-1822.